Marta Martinez-Vicente, PhD
Autophagy and Lysosomal Dysfunction Lab
Neurodegenerative Diseases Research Group
Vall d’Hebron Research Institute (VHIR)-CIBERNED-UAB
The main focus of our research is to study the role of autophagy in neurodegeneration. Alterations in the autophagy process have been associated with neurodegenerative diseases including Parkinson’s, Huntington’s and Alzheimer’s disease and has been shown to be one of the main causes that contribute to neuronal death in these pathologies. Our efforts are currently directed to:
- Development of new therapies for Parkinson’s disease based in the restoration of lysosomal glucocerebrosidase (GBA) activity.
- Development of new autophagy pharmacological modulators (mTOR-independent) as a therapeutic strategy in neurodegenerative diseases.
- Characterize the defective lysosomal-mediated turnover of mitocondria and aggregates in Huntington’s disease and its contribution to neurodegeneration.