MIGUEL A. PEÑALVA

Autofagosomas LC-3/Atg8-GFP creciendo en la proximidad de lysosomas /vacuolas marcadas con RAB7-magenta. Timer in min:sec

Understanding intracellular traffic and specifically the multiple pathways that lead proteins to the plasma membrane/extracellular milieu using the genetically amenable and microscopy-friendly filamentous fungus Aspergillus nidulans.

We are particularly interested in the interplay between multi-subunit tethering complexes, small GTPases and unconventional modes of secretion that bypass the Golgi. These unconventional routes may hijack autophagosomes for secretory purposes

Aspergillus nidulans is ideally suited to investigate microtubule-dependent traffic, in particular the different types of adapters connecting intracellular vesicles with dynein and kinesins.

Miguel A. Peñalva

Profesor de Investigación CSIC

Centro de Investigaciones Biológicas

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